Article
Whole Genome Doubling mitigates Muller’s Ratchet in Cancer Evolution
2019-01-07
Abstract excerpt
Whole genome doubling (WGD) is a prevalent macro-evolutionary event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and clinical prognostic relevance, the evolutionary selection pressures for WGD have not been investigated. Here, we explored whether WGD may act to mitigate the irreversible, inexorable ratchet-like, accumulation of deleterious mutations in essent...
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Identifiers and source
- Literature Corpus work
- ac26f185-824d-5ee6-bb91-0c6d2a6a56cf
- DOI
- 10.1101/513457