Article

The Breakome of <i>BRCA1</i> and <i>BRCA2</i> Pathway Mutation Carriers Reveals Early Processes in Breast Oncogenesis

2025-09-27

Abstract excerpt

DNA double-strand breaks (DSBs) can lead to genomic instability in cancer. Cells rely on an efficient DNA damage response (DDR) to maintain their DNA integrity and prevent oncogenic transformation. However, the early events that connect recurrent DNA damage to oncogenesis are not yet fully understood. Here, using next generation sequencing we comprehensively surveyed genomes to identify DSBs in primary cells of no...

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Literature Corpus work: dc57e86f-7566-5b9d-b48e-3a690ec8c768
DOI: 10.1101/2025.09.25.678591

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