Article

Tissue-Specific Prevalence and Clonal Architecture of <i>BRCA1/2</i> LOH-Inducing Chromosomal Aneuploidy

2026-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Germline pathogenic variants in BRCA1 and BRCA2 confer disproportionately elevated cancer risks in breast and ovarian tissues, yet the basis for this tissue specificity remains incompletely understood. Here, we integrate bulk-tumor aneuploidy analysis across 340,824 cancer cases from three independent cohorts (TCGA, ICGC PCAWG, and FoundationCore) with single-cell whole-genome sequencing from tw...

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Literature Corpus work: 5e4bf252-18b3-54ba-bc7e-ae099fdb6093
DOI: 10.64898/2026.04.17.718766

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