Article
Mutational processes molding the genomes of 21 breast cancers.
Cell - 25 May 2012
Nik-Zainal Serena, Alexandrov Ludmil B, Wedge David C, Van Loo Peter, Greenman Christopher D, Raine Keiran, Jones David, Hinton Jonathan, Marshall John, Stebbings Lucy A, Menzies Andrew, Martin Sancha, Leung Kenric, Chen Lina, Leroy Catherine, Ramakrishna Manasa, Rance Richard, Lau King Wai, Mudie Laura J, Varela Ignacio, McBride David J, Bignell Graham R, Cooke Susanna L, Shlien Adam, Gamble John, Whitmore Ian, Maddison Mark, Tarpey Patrick S, Davies Helen R, Papaemmanuil Elli, Stephens Philip J, McLaren Stuart, Butler Adam P, Teague Jon W, Jönsson Göran, Garber Judy E, Silver Daniel, Miron Penelope, Fatima Aquila, Boyault Sandrine, Langerød Anita, Tutt Andrew, Martens John W M, Aparicio Samuel A J R, Borg Åke, Salomon Anne Vincent, Thomas Gilles, Børresen-Dale Anne-Lise, Richardson Andrea L, Neuberger Michael S, Futreal P Andrew, Campbell Peter J, Stratton Michael R
Abstract excerpt
All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the DNA damage and repair processes to which cancer cells and their precursors have been exposed. To explore these mechanisms further, we generated catalogs of somatic mutation from 21 breast cancers and applied mathematical methods to extract mutational signatures of the underlying processes. Multiple distinct single- and...
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