Article

Timing the onset of homologous recombination deficiency before cancer diagnosis

2025-10-19

Abstract excerpt

<h4>SUMMARY</h4> Mutations in BRCA1 and BRCA2 , whether inherited or somatically acquired, cause homologous recombination deficiency (HRD) in tumor cells. However, the precise timing of HRD onset in the tumor lineage is unknown. Under the haploinsufficiency model of BRCA1/2 , HRD-associated mutagenesis could begin as early as fertilization, whereas the prevailing two-hit tumor suppressor model places HRD onset...

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Literature Corpus work: 68b63c75-41f5-5e60-bce9-66ff3d25edf3
DOI: 10.1101/2025.10.17.683157

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