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Article

Quantifying rate-limiting genetic variation in breast and ovarian tumourigenesis.

EBioMedicine - 1 Mar 2026

Houlahan Kathleen E, Bihie Mahad, Greatti Yves, Contreras Julián Grandvallet, Fulop Daniel J, Lopez Gonzalo, Williams Marc, Huang Hsin-Hsiung, Van Loo Peter, Boutros Paul C, Huang Kuan-Lin

Abstract excerpt

BACKGROUND: The number and type of genetic alterations required to initiate breast and ovarian cancer remain unclear. While germline BRCA1/2 carriers show markedly elevated cancer risk, it is uncertain whether point mutations or copy number alterations constitute the rate-limiting events of tumourigenesis. METHODS: We developed a statistical framework extending prior incidence-mutation models to estimate the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41724111
DOI: 10.1016/j.ebiom.2026.106181
PMCID: PMC12945530

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

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