Temporal dissection of tumorigenesis in primary cancers.

doi:10.1158/2159-8290.CD-11-0028

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Article

Temporal dissection of tumorigenesis in primary cancers.

Cancer discovery - 1 Jul 2011

Durinck Steffen, Ho Christine, Wang Nicholas J, Liao Wilson, Jakkula Lakshmi R, Collisson Eric A, Pons Jennifer, Chan Sai-Wing, Lam Ernest T, Chu Catherine, Park Kyunghee, Hong Sung-woo, Hur Joe S, Huh Nam, Neuhaus Isaac M, Yu Siegrid S, Grekin Roy C, Mauro Theodora M, Cleaver James E, Kwok Pui-Yan, LeBoit Philip E, Getz Gad, Cibulskis Kristian, Aster Jon C, Huang Haiyan, Purdom Elizabeth, Li Jian, Bolund Lars, Arron Sarah T, Gray Joe W, Spellman Paul T, Cho Raymond J

Abstract excerpt

Timely intervention for cancer requires knowledge of its earliest genetic aberrations. Sequencing of tumors and their metastases reveals numerous abnormalities occurring late in progression. A means to temporally order aberrations in a single cancer, rather than inferring them from serially acquired samples, would define changes preceding even clinically evident disease. We integrate DNA sequence and copy number...

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Identifiers

PMID: 21984974
DOI: 10.1158/2159-8290.CD-11-0028
PMCID: PMC3187561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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