Article
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.
Nature genetics - 1 Mar 2020
López Saioa, Lim Emilia L, Horswell Stuart, Haase Kerstin, Huebner Ariana, Dietzen Michelle, Mourikis Thanos P, Watkins Thomas B K, Rowan Andrew, Dewhurst Sally M, Birkbak Nicolai J, Wilson Gareth A, Van Loo Peter, Jamal-Hanjani Mariam, Swanton Charles, McGranahan Nicholas
Abstract excerpt
Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressures for WGD in cancer have not been investigated. Here, we combine evolutionary simulations with an analysis of cancer sequencing data to explore WGD during cancer evolution. Simulations suggest that WGD can...
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