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Article

Replication fork dynamics and dynamic mutations: the fork-shift model of repeat instability.

Trends in genetics : TIG - 1 May 2005

Cleary John D, Pearson Christopher E

Abstract excerpt

Gene-specific repeat instability is responsible for >36 human diseases. Active instability varies in a tissue-, developmental stage- and locus-specific manner and occurs in both proliferative and non-proliferative cells. In proliferative cells, DNA replication can contribute to repeat instability either by switching the direction of replication, which changes the repeat sequence that serves as the lagging-strand...

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Identifiers

PMID: 15851063
DOI: 10.1016/j.tig.2005.03.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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