DNA replication timing influences gene expression level.

doi:10.1083/jcb.201701061

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Article

DNA replication timing influences gene expression level.

The Journal of cell biology - 3 Jul 2017

Müller Carolin A, Nieduszynski Conrad A

Abstract excerpt

Eukaryotic genomes are replicated in a reproducible temporal order; however, the physiological significance is poorly understood. We compared replication timing in divergent yeast species and identified genomic features with conserved replication times. Histone genes were among the earliest replicating loci in all species. We specifically delayed the replication of HTA1-HTB1 and discovered that this halved the...

Topics

Cell Cycle Proteins
DNA Replication Timing
DNA, Fungal
Gene Expression Regulation, Fungal
Histone Acetyltransferases
Histones
Mutation
Phylogeny
RNA, Fungal
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Time Factors
Transcription, Genetic

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Identifiers

PMID: 28539386
DOI: 10.1083/jcb.201701061
PMCID: PMC5496624

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