Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.

Nature - 10 Dec 2009

Gostissa Monica, Yan Catherine T, Bianco Julia M, Cogné Michel, Pinaud Eric, Alt Frederick W

Abstract excerpt

B-cell malignancies, such as human Burkitt's lymphoma, often contain translocations that link c-myc or other proto-oncogenes to the immunoglobulin heavy chain locus (IgH, encoded by Igh). The nature of elements that activate oncogenes within such translocations has been a long-standing question. Translocations within Igh involve DNA double-strand breaks initiated either by the RAG1/2 endonuclease during variable,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Breakpoints
Share to Gene Rearrangement, B-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin Heavy Chain

Share to Genes, myc

Share to Immunoglobulin Class Switching

Share to Lymphoma, B-Cell

Share to Regulatory Sequences, Nucleic Acid

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20010689
DOI: 10.1038/nature08633
PMCID: PMC2802177

Genes

AICDA
RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.PMID 20010689Read ↗

The 3' IgH locus control region is sufficient to deregulate a c-myc transgene and promote mature B cell malignancies with a predominant Burkitt-like phenotype.Semantic proximity Read ↗

Regulatory elements in the immunoglobulin heavy chain gene 3'-enhancers induce c-myc deregulation and lymphomagenesis in murine B cells.Semantic proximity Read ↗

The IgH 3′ regulatory region and its implication in lymphomagenesisSemantic proximity Read ↗

B-cell tumorigenesis in mice carrying a yeast artificial chromosome-based immunoglobulin heavy/c-myc translocus is independent of the heavy chain intron enhancer (Emu).Semantic proximity Read ↗

Uncoupling between Ig somatic hypermutation and oncogene mutation in mouse lymphoma.Semantic proximity Read ↗

Activated mature B cells undergo enforced Sµ-3'RRrec in the λ-c-MYC mouse modelSemantic proximity Read ↗

Human antibody heavy chain variable region exon interacts with 3’ regulatory region to form a stable somatic hypermutation centerSemantic proximity Read ↗

Insertion of c- Myc into Igh Induces B-Cell and Plasma-Cell Neoplasms in MiceSemantic proximity Read ↗

Isolation of region-specific factors assembled on the Immunoglobulin heavy chain locus during antibody class switch recombinationSemantic proximity Read ↗

The spectrum of immunoglobulin heavy chain enhancer hijacking in chronic lymphocytic leukemia.Semantic proximity Read ↗

Restricting activation‐induced cytidine deaminase tumorigenic activity in B lymphocytesSemantic proximity Read ↗

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.