Article

Activated mature B cells undergo enforced Sµ-3'RRrec in the λ-c-MYC mouse model

2024-10-29

Abstract excerpt

<title>Abstract</title> <p>The Sµ-3'RR recombination (Sµ-3'RRrec) in B cells, a genomic rearrangement occurring within the immunoglobulin heavy chain (IGH) locus is believed to lead to B cell receptor (BCR) loss. Its increased frequency in patients with chronic lymphocytic leukemia (CLL), especially those with high <italic>MYC</italic> expression, suggests c-MYC contribute to genetic instability during oncogenesi...

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Literature Corpus work: 001ad0ad-328b-5b1d-918a-6c0c4a6c5660
DOI: 10.21203/rs.3.rs-5331665/v1

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