Somatic hypermutation mechanisms during lymphomagenesis and transformation.

doi:10.1016/j.gde.2024.102165

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Article

Somatic hypermutation mechanisms during lymphomagenesis and transformation.

Current opinion in genetics & development - 1 Apr 2024

Lauring Max C, Basu Uttiya

Abstract excerpt

B cells undergoing physiologically programmed or aberrant genomic alterations provide an opportune system to study the causes and consequences of genome mutagenesis. Activated B cells in germinal centers express activation-induced cytidine deaminase (AID) to accomplish physiological somatic hypermutation (SHM) of their antibody-encoding genes. In attempting to diversify their immunoglobulin (Ig) heavy- and...

Topics

Genomics
Hydantoins
Mutation
Nitrogen Mustard Compounds

Source

Open in PubMed

Identifiers

PMID: 38428317
DOI: 10.1016/j.gde.2024.102165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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