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Article

Overlapping hotspots in CDRs are critical sites for V region diversification.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2015

Wei Lirong, Chahwan Richard, Wang Shanzhi, Wang Xiaohua, Pham Phuong T, Goodman Myron F, Bergman Aviv, Scharff Matthew D, MacCarthy Thomas

Abstract excerpt

Activation-induced deaminase (AID) mediates the somatic hypermutation (SHM) of Ig variable (V) regions that is required for the affinity maturation of the antibody response. An intensive analysis of a published database of somatic hypermutations that arose in the IGHV3-23*01 human V region expres...

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Source

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Identifiers

PMID: 25646473
DOI: 10.1073/pnas.1500788112
PMCID: PMC4343087

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25646473-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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