Article

Contribution of the IGCR1 regulatory element and the 3 <i>’Igh</i> CBEs to Regulation of <i>Igh</i> V(D)J Recombination

2023-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Immunoglobulin heavy chain variable region exons are assembled in progenitor-B cells, from V H , D, and J H gene segments located in separate clusters across the Igh locus. RAG endonuclease initiates V(D)J recombination from a J H -based recombination center (RC). Cohesin-mediated extrusion of upstream chromatin past RC-bound RAG presents Ds for joining to J H s to form a DJ H -RC. Igh ha...

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Literature Corpus work: f1dca78d-7fab-5080-a28a-da4c39d420aa
DOI: 10.1101/2023.04.21.537836

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