Article

A structure-informed deep learning framework for modeling TCR-peptide-HLA interactions

2026-04-02

Abstract excerpt

The interaction between T cell receptors (TCRs), peptides, and human leukocyte antigens (HLAs) underlies antigen-specific T cell immunity. Despite substantial advances in peptide– HLA presentation prediction, accurate modeling of coupled TCR–peptide–HLA recognition remains underdeveloped, limiting applications such as TCR and neoepitope prioritization in cancer and antigen identification in autoimmunity. Here we p...

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Literature Corpus work: da35c4f8-cb4f-588f-85e0-47b93cd2a270
DOI: 10.64898/2026.03.31.715361

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