Article

Predicting specificity of TCR-pMHC interactions using machine learning and biophysical models

2025-04-07

Abstract excerpt

Understanding the mechanism of T-cell activation and T-cell receptor (TCR) discrimination of MHC-presented epitope peptides (pMHCs) remains an open problem. Machine learning (ML)-based prediction of TCR specificity has gained considerable recent attention. However, the capacity of current models to generalize to peptides unseen during training is currently unknown. Here, we use a proprietary cancer-patient data se...

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Literature Corpus work: 675f72d7-e196-5552-aeac-1f421c604ec6
DOI: 10.1101/2025.04.04.647165

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