Article

Altered neocortical gene expression, brain overgrowth and functional over-connectivity in <i>Chd8</i> haploinsufficient mice

2017-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Truncating CHD8 mutations are amongst the highest confidence risk factors for autism spectrum disorders (ASD) identified to date. Here, we report that Chd8 heterozygous mice display increased brain size, motor delay, hypertelorism, pronounced hypoactivity and anomalous responses to social stimuli. Whereas gene expression in the neocortex is only mildly affected at mid-gestation, over 600 genes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10a37c08-9118-543f-ab0b-59c7a5995c49
DOI: 10.1101/143552

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Altered neocortical gene expression, brain overgrowth and functional over-connectivity in <i>Chd8</i> haploinsufficient miceDOI 10.1101/143552Read

Heterozygous mutation to <i>Chd8</i> causes macrocephaly and widespread alteration of neurodevelopmental transcriptional networks in mouseSemantic proximity Read

Neurodevelopmental functions of CHD8: new insights and questions.Semantic proximity Read

Germline Chd8 haploinsufficiency alters brain development in mouse.Semantic proximity Read

CHD8 haploinsufficiency results in autistic-like phenotypes in mice.Semantic proximity Read

Cell type-specific dysregulation of gene expression due to <i>Chd8</i> haploinsufficiency during mouse cortical developmentSemantic proximity Read

Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life.Semantic proximity Read

Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice.Semantic proximity Read

Homozygous loss of autism-risk gene <i>CNTNAP2</i> results in reduced local and long-range prefrontal functional connectivitySemantic proximity Read

Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of <i>CHD8</i> heterozygous cerebral organoidsSemantic proximity Read

Male-Dominant Effects of Chd8 Haploinsufficiency on Synaptic Phenotypes during Development in Mouse Prefrontal Cortex.Semantic proximity Read

Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development.Semantic proximity Read

Disruptive CHD8 mutations define a subtype of autism early in development.Semantic proximity Read