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Article

Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development.

Molecular autism - 24 Feb 2021

Hurley Shaun, Mohan Conor, Suetterlin Philipp, Ellingford Robert, Riegman Kimberley L H, Ellegood Jacob, Caruso Angela, Michetti Caterina, Brock Olivier, Evans Romy, Rudari Fabrizio, Delogu Alessio, Scattoni Maria Luisa, Lerch Jason P, Fernandes Cathy, Basson M Albert

Abstract excerpt

BACKGROUND: CHD8 haploinsufficiency causes autism and macrocephaly with high penetrance in the human population. Chd8 heterozygous mice exhibit relatively subtle brain overgrowth and little gene expression changes in the embryonic neocortex. The purpose of this study was to generate new, sub-haploinsufficient Chd8 mouse models to allow us to identify and study the functions of CHD8 during embryonic cortical...

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Identifiers

PMID: 33627187
DOI: 10.1186/s13229-020-00409-3
PMCID: PMC7905672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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