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Article

Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice.

Molecular psychiatry - 1 Jul 2021

Ellingford Robert A, Panasiuk Martyna J, de Meritens Emilie Rabesahala, Shaunak Raghav, Naybour Liam, Browne Lorcan, Basson M Albert, Andreae Laura C

Abstract excerpt

Heterozygous mutation of chromodomain helicase DNA binding protein 8 (CHD8) is strongly associated with autism spectrum disorder (ASD) and results in dysregulated expression of neurodevelopmental and synaptic genes during brain development. To reveal how these changes affect ASD-associated cortical circuits, we studied synaptic transmission in the prefrontal cortex of a haploinsufficient Chd8 mouse model. We...

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Identifiers

PMID: 33837267
DOI: 10.1038/s41380-021-01070-9
PMCID: PMC8505247

Genes

CHD8

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