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Article

Heterozygous mutation to <i>Chd8</i> causes macrocephaly and widespread alteration of neurodevelopmental transcriptional networks in mouse

2016-09-20

Abstract excerpt

<h4>Summary</h4> The chromatin remodeling gene CHD8 represents a central node in early neurodevelopmental gene networks implicated in autism. We examined the impact of heterozygous germline Chd8 mutation on neurodevelopment in mice. Network analysis of neurodevelopmental gene expression revealed subtle yet strongly significant widespread transcriptional changes in Chd8 +/− mice across autism-relevant networks...

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Literature Corpus work
ab525426-ecfa-5d94-ab01-10010a2fcda3
DOI
10.1101/076158
Open publication

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Heterozygous mutation to <i>Chd8</i> causes macrocephaly and widespread alteration of neurodevelopmental transcriptional networks in mouseDOI 10.1101/076158
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