Article

Homozygous loss of autism-risk gene <i>CNTNAP2</i> results in reduced local and long-range prefrontal functional connectivity

2016-06-29

Abstract excerpt

Functional connectivity aberrancies, as measured with resting-state fMRI (rsfMRI), have been consistently observed in the brain of autism spectrum disorders (ASD) patients. However, the genetic and neurobiological underpinnings of these findings remain unclear. Homozygous mutations in Contactin Associated Protein-like 2 (CNTNAP2), a neurexin-related cell-adhesion protein, are strongly linked to autism and epilepsy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fbdbd177-e7b4-5b83-acbf-c3b672ec82a9
DOI: 10.1101/060335

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Homozygous loss of autism-risk gene <i>CNTNAP2</i> results in reduced local and long-range prefrontal functional connectivityDOI 10.1101/060335Read

Homozygous Loss of Autism-Risk Gene CNTNAP2 Results in Reduced Local and Long-Range Prefrontal Functional Connectivity.Semantic proximity Read

Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2.Semantic proximity Read

Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypesSemantic proximity Read

Altered neocortical gene expression, brain overgrowth and functional over-connectivity in <i>Chd8</i> haploinsufficient miceSemantic proximity Read

Reproducible functional connectivity alterations are associated with autism spectrum disorderSemantic proximity Read

Selective Dysregulation of Hippocampal Inhibition in the Mouse Lacking Autism Candidate Gene CNTNAP2.Semantic proximity Read

A cross-species link between mTOR-related synaptic pathology and functional hyperconnectivity in autismSemantic proximity Read

Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndromeSemantic proximity Read

Loss of function in the autism and learning disabilities associated gene <i>Nf1</i> disrupts corticocortical and corticostriatal functional connectivity in human and mouseSemantic proximity Read

Large-scale topology and the default mode network in the mouse connectomeSemantic proximity Read

Reduced prefrontal synaptic connectivity and disturbed oscillatory population dynamics in the CNTNAP2 model of autismSemantic proximity Read

ASD-Associated <i>CNTNAP2</i> Variants Disrupt Neuronal Arborization Through Impaired Regulation by Ectodomain SheddingSemantic proximity Read