Article
Germline Chd8 haploinsufficiency alters brain development in mouse.
Nature neuroscience - 1 Aug 2017
Gompers Andrea L, Su-Feher Linda, Ellegood Jacob, Copping Nycole A, Riyadh M Asrafuzzaman, Stradleigh Tyler W, Pride Michael C, Schaffler Melanie D, Wade A Ayanna, Catta-Preta Rinaldo, Zdilar Iva, Louis Shreya, Kaushik Gaurav, Mannion Brandon J, Plajzer-Frick Ingrid, Afzal Veena, Visel Axel, Pennacchio Len A, Dickel Diane E, Lerch Jason P, Crawley Jacqueline N, Zarbalis Konstantinos S, Silverman Jill L, Nord Alex S
Abstract excerpt
The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8+/del5 mice displayed normal social interactions with no repetitive behaviors but exhibited cognitive impairment correlated with increased regional brain volume, validating that phenotypes of...
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