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Article

Male-Dominant Effects of Chd8 Haploinsufficiency on Synaptic Phenotypes during Development in Mouse Prefrontal Cortex.

ACS chemical neuroscience - 17 Apr 2024

Ellingford Robert A, Tojo Mizuki, Basson M Albert, Andreae Laura C

Abstract excerpt

CHD8 is a high penetrance, high confidence risk gene for autism spectrum disorder (ASD), a neurodevelopmental disorder that is substantially more prevalent among males than among females. Recent studies have demonstrated variable sex differences in the behaviors and synaptic phenotypes of mice carrying different heterozygous ASD-associated mutations in Chd8. We examined functional and structural cellular...

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Identifiers

PMID: 38557009
DOI: 10.1021/acschemneuro.3c00690
PMCID: PMC11027092

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Male-Dominant Effects of Chd8 Haploinsufficiency on Synaptic Phenotypes during Development in Mouse Prefrontal Cortex.PMID 38557009Read ↗

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