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Article

CHD8 haploinsufficiency results in autistic-like phenotypes in mice.

Nature - 29 Sept 2016

Katayama Yuta, Nishiyama Masaaki, Shoji Hirotaka, Ohkawa Yasuyuki, Kawamura Atsuki, Sato Tetsuya, Suyama Mikita, Takumi Toru, Miyakawa Tsuyoshi, Nakayama Keiichi I

Abstract excerpt

Autism spectrum disorder (ASD) comprises a range of neurodevelopmental disorders characterized by deficits in social interaction and communication as well as by restricted and repetitive behaviours. ASD has a strong genetic component with high heritability. Exome sequencing analysis has recently identified many de novo mutations in a variety of genes in individuals with ASD, with CHD8, a gene encoding a chromatin...

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Source

Identifiers

PMID: 27602517
DOI: 10.1038/nature19357

Genes

CHD8
REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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