Article

Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer

2022-04-26

Abstract excerpt

A prominent source of mutation in cancer is single-stranded DNA cytosine deamination by cellular APOBEC3 enzymes, which results in signature C-to-T and C-to-G mutations in TCA and TCT motifs. Although multiple enzymes have been implicated, reports conflict and it is unclear which protein(s) are responsible. Here we report the development of a selectable system to quantify genome mutation and demonstrate its utilit...

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Literature Corpus work: 1084b763-8216-5baa-bbf9-7313e97df2c5
DOI: 10.1101/2022.04.26.489523

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