Article
An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.
Nature genetics - 1 Sept 2015
Chan Kin, Roberts Steven A, Klimczak Leszek J, Sterling Joan F, Saini Natalie, Malc Ewa P, Kim Jaegil, Kwiatkowski David J, Fargo David C, Mieczkowski Piotr A, Getz Gad, Gordenin Dmitry A
Abstract excerpt
Elucidation of mutagenic processes shaping cancer genomes is a fundamental problem whose solution promises insights into new treatment, diagnostic and prevention strategies. Single-strand DNA-specific APOBEC cytidine deaminase(s) are major source(s) of mutation in several cancer types. Previous indirect evidence implicated APOBEC3B as the more likely major mutator deaminase, whereas the role of APOBEC3A is not...
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