Article
Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer.
PLoS genetics - 1 Nov 2023
Carpenter Michael A, Temiz Nuri A, Ibrahim Mahmoud A, Jarvis Matthew C, Brown Margaret R, Argyris Prokopios P, Brown William L, Starrett Gabriel J, Yee Douglas, Harris Reuben S
Abstract excerpt
A prominent source of mutation in cancer is single-stranded DNA cytosine deamination by cellular APOBEC3 enzymes, which results in signature C-to-T and C-to-G mutations in TCA and TCT motifs. Although multiple enzymes have been implicated, reports conflict and it is unclear which protein(s) are responsible. Here we report the development of a selectable system to quantify genome mutation and demonstrate its...
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