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Article

Defining APOBEC-induced mutation signatures and modifying activities in yeast.

Methods in enzymology - 1 Jan 2025

Mertz Tony M, Kockler Zachary W, Coxon Margo, Cordero Cameron, Raval Atri K, Brown Alexander J, Harcy Victoria, Gordenin Dmitry A, Roberts Steven A

Abstract excerpt

APOBEC cytidine deaminases guard cells in a variety of organisms from invading viruses and foreign nucleic acids. Recently, several human APOBECs have been implicated in mutating evolving cancer genomes. Expression of APOBEC3A and APOBEC3B in yeast allowed experimental derivation of the substitution patterns they cause in dividing cells, which provided critical links to these enzymes in the etiology of the COSMIC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40250951
DOI: 10.1016/bs.mie.2024.11.041
PMCID: PMC12324072

Genes

APOBEC3A
APOBEC3B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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