Article

The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences

2024-01-16

Abstract excerpt

APOBEC proteins are cytidine deaminases that restrict the replication of viruses and transposable elements. Several members of the APOBEC3 family, APOBEC3A, APOBEC3B, and APOBEC3H-I, can access the nucleus and cause what is thought to be indiscriminate deamination of the genome, resulting in mutagenesis and genome instability. Although APOBEC3C is also present in the nucleus, its deamination target preferences are...

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Literature Corpus work: b15c1576-9b21-541d-9b42-51317f20b972
DOI: 10.1101/2024.01.15.575754

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