Article

<i>Drosophila SA1</i> expression prevents brain tumorigenesis and PARP-mediated cell elimination

2025-04-23

Abstract excerpt

<h4>ABSTRACT</h4> The cohesin complex performs essential cellular functions including regulation of chromosome cohesion, chromatin organization and DNA repair. Somatic pathogenetic variants in cohesin genes, such as STAG2 , have been associated with cancer, but their contribution to brain tumorigenesis is unclear. Here, we report the presence of STAG2 variants in glioblastoma and medulloblastoma patients and de...

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Literature Corpus work: 107b70fe-a7ea-5aa8-9a7b-79192de3bf7c
DOI: 10.1101/2025.04.18.649500

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