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Article

STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM Inhibition

20 Nov 2023

Abstract excerpt

Stromal antigen 2 (STAG2), a subunit of the cohesin complex, is recurrently mutated in various tumors. However, the role of STAG2 in DNA repair and its therapeutic implications are largely unknown. Here it is reported that knockout of STAG2 results in increased double-stranded breaks (DSBs) and chromosomal aberrations by reducing homologous recombination (HR) repair, and confers hypersensitivity to inhibitors of...

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PMID: 37985839
DOI: 10.1002/advs.202302494

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