Article

STAG2 promotes the myelination transcriptional program in oligodendrocytes

2021-10-12

Abstract excerpt

<h4>SUMMARY</h4> Cohesin folds chromosomes via DNA loop extrusion. Cohesin-mediated chromosome loops regulate transcription by shaping long-range enhancer-promoter interactions, among other mechanisms. Mutations of cohesin subunits and regulators cause human developmental diseases termed cohesinopathy. Vertebrate cohesin consists of SMC1, SMC3, RAD21, and either STAG1 or STAG2. To probe the physiological function...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f8438e6-0562-5804-a798-27aaa837a7ab
DOI: 10.1101/2021.10.10.463866

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

STAG2 promotes the myelination transcriptional program in oligodendrocytesDOI 10.1101/2021.10.10.463866Read

STAG2 promotes the myelination transcriptional program in oligodendrocytes.Semantic proximity Read

STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiformeSemantic proximity Read

The INO80 chromatin remodeling complex regulates histone H2A.Z mobility and the G1-S transition in oligodendrocyte precursorsSemantic proximity Read

STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cellsSemantic proximity Read

STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme.Semantic proximity Read

Cohesinopathies, gene expression, and chromatin organization.Semantic proximity Read

SMC complexes link gene expression and genome architecture.Semantic proximity Read

Somatic mosaicism in STAG2-associated cohesinopathies: Expansion of the genotypic and phenotypic spectrumSemantic proximity Read

The N-terminus of Stag1 is required to repress the 2C program by maintaining rRNA expression and nucleolar integritySemantic proximity Read

Low tolerance for transcriptional variation at cohesin genes is accompanied by functional links to disease-relevant pathwaysSemantic proximity Read

Sox2-dependent maintenance of mouse oligodendroglioma involves the Sox2-mediated downregulation of Cdkn2b, Ebf1, Zfp423 and Hey2Semantic proximity Read

Cohesin complex-associated holoprosencephalySemantic proximity Read