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Article

Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition.

Molecular cancer therapeutics - 1 Mar 2014

Bailey Melanie L, O'Neil Nigel J, van Pel Derek M, Solomon David A, Waldman Todd, Hieter Philip

Abstract excerpt

Recent data have identified STAG2, a core subunit of the multifunctional cohesin complex, as a highly recurrently mutated gene in several types of cancer. We sought to identify a therapeutic strategy to selectively target cancer cells harboring inactivating mutations of STAG2 using two independent pairs of isogenic glioblastoma cell lines containing either an endogenous mutant STAG2 allele or a wild-type STAG2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24356817
DOI: 10.1158/1535-7163.MCT-13-0749
PMCID: PMC4130349

Genes

STAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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