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DHX15 inhibits mouse APOBEC3 deamination

2024-08-19

Abstract excerpt

APOBEC3 family proteins are critical host factors that counteract and prevent the replication of retroviruses and other viruses through cytidine deamination. Human APOBEC3 proteins inactivate HIV-1 through the introduction of lethal mutations to viral genomes. In contrast, mouse APOBEC3 does not induce DNA hypermutation of murine retroviruses, although it retains functional cytidine deaminase activity. Why mouse A...

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Identifiers and source

Literature Corpus work
10554963-8f49-5504-83a7-ece3827d7174
DOI
10.1101/2024.08.19.608612
Open publication

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DHX15 inhibits mouse APOBEC3 deaminationDOI 10.1101/2024.08.19.608612
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