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Article

New antiviral target revealed by the hexameric structure of mouse hepatitis virus nonstructural protein nsp15.

Journal of virology - 1 Aug 2006

Xu Xiaoling, Zhai Yujia, Sun Fei, Lou Zhiyong, Su Dan, Xu Yuanyuan, Zhang Rongguang, Joachimiak Andrzej, Zhang Xuejun C, Bartlam Mark, Rao Zihe

Abstract excerpt

The unique coronavirus transcription/replication machinery comprised of multiple virus-encoded nonstructural proteins (nsp) plays a vital role during initial and intermediate phases of the viral life cycle. The crystal structure of mouse hepatitis virus strain A59 (MHV-A59) nsp15 is reported at 2.15-A resolution. nsp15 is an XendoU endoribonuclease and is the first one from this family to have its structure...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16873248
DOI: 10.1128/JVI.00525-06
PMCID: PMC1563835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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