Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.

doi:10.1016/j.jmb.2008.10.043

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Article

Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.

Journal of molecular biology - 9 Jan 2009

Petit Vincent, Guétard Denise, Renard Myrtille, Keriel Anne, Sitbon Marc, Wain-Hobson Simon, Vartanian Jean-Pierre

Abstract excerpt

Mammalian APOBEC molecules comprise a large family of cytidine deaminases with specificity for RNA and single-stranded DNA (ssDNA). APOBEC1s are invariably highly specific and edit a single residue in a cellular mRNA, while the cellular targets for APOBEC3s are not clearly established, although they may curtail the transposition of some retrotransposons. Two of the seven member human APOBEC3 enzymes strongly...

Topics

APOBEC Deaminases
APOBEC-1 Deaminase
Animals
Animals, Newborn
Apolipoproteins B
Base Sequence
Cytidine Deaminase
DNA, Complementary
Genome, Viral
Humans
Hypoxanthine Phosphoribosyltransferase
Leukemia Virus, Murine
Leukemia, Experimental

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Mice

Molecular Sequence Data

Muscle Proteins

Mutation

NIH 3T3 Cells

Source

Open in PubMed

Identifiers

PMID: 18983852
DOI: 10.1016/j.jmb.2008.10.043

Genes

APOBEC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.