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Deaminase-Dead Mouse APOBEC3 Is an In Vivo Retroviral Restriction Factor

26 Mar 2018

Abstract excerpt

ABSTRACT The apolipoprotein B editing complex 3 (APOBEC3) proteins are potent retroviral restriction factors that are under strong positive selection, both in terms of gene copy number and sequence diversity. A common feature of all the members of the APOBEC3 family is the presence of one or two cytidine deamination domains, essential for cytidine deamination of retroviral reverse transcripts as well as packaging...

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PMID: 29593034
DOI: 10.1128/jvi.00168-18

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