Article
The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.
Science signaling - 29 Apr 2014
Mosallanejad Kenta, Sekine Yusuke, Ishikura-Kinoshita Seiko, Kumagai Kazuo, Nagano Tetsuo, Matsuzawa Atsushi, Takeda Kohsuke, Naguro Isao, Ichijo Hidenori
Abstract excerpt
During infection with an RNA virus, the DExD/H-box RNA helicases RIG-I (retinoic acid-inducible gene I) and MDA5 (melanoma differentiation-associated gene 5) activate the interferon regulatory factor 3 (IRF3), nuclear factor κB (NF-κB), c-Jun amino-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways through an unknown mechanism involving the adaptor protein MAVS...
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