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Article

DNA deamination mediates innate immunity to retroviral infection.

Cell - 13 Jun 2003

Harris Reuben S, Bishop Kate N, Sheehy Ann M, Craig Heather M, Petersen-Mahrt Svend K, Watt Ian N, Neuberger Michael S, Malim Michael H

Abstract excerpt

CEM15/APOBEC3G is a cellular protein required for resistance to infection by virion infectivity factor (Vif)-deficient human immunodeficiency virus (HIV). Here, using a murine leukemia virus (MLV)-based system, we provide evidence that CEM15/APOBEC3G is a DNA deaminase that is incorporated into virions during viral production and subsequently triggers massive deamination of deoxycytidine to deoxyuridine within...

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Source

Identifiers

PMID: 12809610
DOI: 10.1016/s0092-8674(03)00423-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA deamination mediates innate immunity to retroviral infection.PMID 12809610Read ↗

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