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Studies on the Restriction of Murine Leukemia Viruses by Mouse APOBEC3

29 May 2012

Abstract excerpt

APOBEC3 proteins function to restrict the replication of retroviruses. One mechanism of this restriction is deamination of cytidines to uridines in (-) strand DNA, resulting in hypermutation of guanosines to adenosines in viral (+) strands. However, Moloney murine leukemia virus (MoMLV) is partially resistant to restriction by mouse APOBEC3 (mA3) and virtually completely resistant to mA3-induced hypermutation. In...

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PMID: 22666481
DOI: 10.1371/journal.pone.0038190

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