Article

Insights for disease modeling from single cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

2022-06-16

Abstract excerpt

<h4>ABSTRACT</h4> Trans-differentiation of human induced pluripotent stem cells into neurons via Ngn2-induction (hiPSC-N) has become an efficient system to quickly generate neurons for disease modeling and in vitro assay development, a significant advance from previously used neoplastic and other cell lines. Recent single-cell interrogation of Ngn2-induced neurons however, has revealed some similarities to unexp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 808bca0e-58a2-50b3-bba2-a68e03ffb9aa
DOI: 10.1101/2022.06.15.495952

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Insights for disease modeling from single cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-cultureDOI 10.1101/2022.06.15.495952Read

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCsSemantic proximity Read

Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cellsSemantic proximity Read

Comprehensive Characterization of the Human Neural Stem Cell Line HNSC.100 as a Versatile Model for Neurobiological ResearchSemantic proximity Read

Early Reprogramming Intermediates Enable Direct Neuronal Conversion via NGN2Semantic proximity Read

Expanding GABAergic Neuronal Diversity in PSC-Derived Disease ModelsSemantic proximity Read

Ngn2 induces diverse neuronal lineages from human pluripotencySemantic proximity Read

A multi-omics approach to visualize early neuronal differentiation in 4DSemantic proximity Read

Early Reprogramming Intermediates Enable Direct Neuronal Conversion via NGN2Semantic proximity Read

Deciphering the protein dynamics and molecular determinants of iPSC-derived neuronsSemantic proximity Read

An integrated transcriptomic cell atlas of human neural organoidsSemantic proximity Read

Long-term co-maturation of stem cell-derived microglia and neuronal networks: an optimized platform to assess human microglial contribution to neuronal functionSemantic proximity Read

Navigating Human Astrocyte Differentiation: Direct and Rapid one-step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network developmentSemantic proximity Read