Article

Ngn2 induces diverse neuronal lineages from human pluripotency

2020-11-19

Abstract excerpt

Human neurons engineered from induced pluripotent stem cells (iPSCs) through Neurogenin 2 (Ngn2) overexpression are widely used to study neuronal differentiation mechanisms and to model neurological diseases. However, the differentiation paths and heterogeneity of emerged neurons have not been fully explored. Here we used single-cell transcriptomics to dissect the cell states that emerge during Ngn2 overexpression...

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Literature Corpus work: a2f1fe59-6239-525d-a79e-521511cc460e
DOI: 10.1101/2020.11.19.389445

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