Article
Expandable and Rapidly Differentiating Human Induced Neural Stem Cell Lines for Multiple Tissue Engineering Applications.
Stem cell reports - 13 Sept 2016
Cairns Dana M, Chwalek Karolina, Moore Yvonne E, Kelley Matt R, Abbott Rosalyn D, Moss Stephen, Kaplan David L
Abstract excerpt
Limited availability of human neurons poses a significant barrier to progress in biological and preclinical studies of the human nervous system. Current stem cell-based approaches of neuron generation are still hindered by prolonged culture requirements, protocol complexity, and variability in neuronal differentiation. Here we establish stable human induced neural stem cell (hiNSC) lines through the direct...
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