MitoTracer facilitates the identification of informative mitochondrial mutations for precise lineage reconstruction.

Abstract excerpt

Mitochondrial (MT) mutations serve as natural genetic markers for inferring clonal relationships using single cell sequencing data. However, the fundamental challenge of MT mutation-based lineage tracing is automated identification of informative MT mutations. Here, we introduced an open-source computational algorithm called "MitoTracer", which accurately identified clonally informative MT mutations and inferred...

Topics

• Humans
• Mutation
• Algorithms
• Computational Biology
• Mitochondria
• Single-Cell Analysis
• Cell Lineage