Article

Inference of Single-Cell Phylogenies from Lineage Tracing Data

2019-10-10

Abstract excerpt

The pairing of CRISPR/Cas9-based gene editing with massively parallel single-cell readouts now enables large-scale lineage tracing. However, the rapid growth in complexity of data from these assays has outpaced our ability to accurately infer phylogenetic relationships. To address this, we provide three resources. First, we introduce Cassiopeia - a suite of scalable and theoretically grounded maximum parsimony app...

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Literature Corpus work: 58f23648-6192-5f94-99e3-356114809372
DOI: 10.1101/800078

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