Article

PhyloSOLID: Robust phylogeny reconstruction from single-cell data despite inherent error and sparsity

2026-02-06

Abstract excerpt

While lineage tracing based on somatic mutations in single-cell sequencing data offers a powerful approach to reconstructing cellular histories in vivo, its reliability is fundamentally limited by pervasive technical artifacts—specifically, high error rates and data sparsity. These issues introduce false phylogenetic signals that corrupt tree topology and lead to spurious evolutionary conclusions. To overcome thes...

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Literature Corpus work: b63b5ed4-e8df-573d-b62d-27013b74f091
DOI: 10.64898/2026.02.04.703905

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