Article

Hypothesis-free detection of gene-interaction effects on biomarker concentration in UK Biobank using variance prioritisation

2022-01-05

Abstract excerpt

Blood biomarkers include disease intervention targets that may interact with genetic and environmental factors resulting in subgroups of individuals who respond differently to treatment. Such interactions may be observed in genetic effects on trait variance. Variance prioritisation is an approach to identify genetic loci with interaction effects by estimating their association with trait variance, even where the m...

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Literature Corpus work: 0fd3040e-30ae-5249-80ad-769becf05b99
DOI: 10.1101/2022.01.05.21268406

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