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Article

Analyses of biomarker traits in diverse UK biobank participants identify associations missed by European-centric analysis strategies.

Journal of human genetics - 1 Feb 2022

Sun Quan, Graff Misa, Rowland Bryce, Wen Jia, Huang Le, Miller-Fleming Tyne W, Haessler Jeffrey, Preuss Michael H, Chai Jin-Fang, Lee Moa P, Avery Christy L, Cheng Ching-Yu, Franceschini Nora, Sim Xueling, Cox Nancy J, Kooperberg Charles, North Kari E, Li Yun, Raffield Laura M

Abstract excerpt

Despite the dramatic underrepresentation of non-European populations in human genetics studies, researchers continue to exclude participants of non-European ancestry, as well as variants rare in European populations, even when these data are available. This practice perpetuates existing research disparities and can lead to important and large effect size associations being missed. Here, we conducted genome-wide...

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Identifiers

PMID: 34376796
DOI: 10.1038/s10038-021-00968-0
PMCID: PMC8792153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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