Article

Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers

2021-11-10

Abstract excerpt

<h4>ABSTRACT</h4> Gene-environment interactions (GEIs) represent the modification of genetic effects by environmental exposures and are critical for understanding disease and informing personalized medicine. GEIs often induce differential phenotypic variance across genotypes; these variance-quantitative trait loci (vQTLs) can be prioritized in a two-stage GEI detection strategy to greatly reduce the computational...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8ee75c5a-7828-5bc7-a0f7-d2e692736ca3
DOI: 10.1101/2021.11.08.21265930

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkersDOI 10.1101/2021.11.08.21265930Read

Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers.Semantic proximity Read

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK BiobankSemantic proximity Read

Gene-based map of cardiometabolic diseasesSemantic proximity Read

Large-scale genome-wide interaction analyses on multiple cardiometabolic risk factors to identify age-specific genetic risk factors.Semantic proximity Read

Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.Semantic proximity Read

An approach to identify gene-environment interactions and reveal new biological insight in complex traits.Semantic proximity Read

Multiancestry Study of Gene-Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts: Design and Rationale.Semantic proximity Read

Gene-lifestyle interactions in the genomics of human complex traits.Semantic proximity Read

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK BiobankSemantic proximity Read

The heritable basis of gene-environment interactions in cardiometabolic traits.Semantic proximity Read

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.Semantic proximity Read

Pleiotropic and sex-specific genetic architecture of circulating metabolic markersSemantic proximity Read